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Provigil
Modafinil (moe daf' i nil)

Brand Name: Provigil

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Prescription Provigil for Sleep Disorders Drug Information

Provigil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Provigil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). Provigil is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

What side effects can I expect when taking Provigil for sleep disorders?

Provigil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • headache
  • dizziness
  • difficulty falling asleep or staying asleep
  • drowsiness
  • nausea
  • diarrhea
  • constipation
  • gas
  • heartburn
  • loss of appetite
  • unusual tastes
  • dry mouth
  • excessive thirst
  • nosebleed
  • flushing
  • sweating
  • tight muscles or difficulty moving
  • back pain
  • confusion
  • uncontrollable shaking of a part of your body
  • burning, tingling, or numbness of the skin
  • difficulty seeing or eye pain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • rash
  • blisters
  • peeling skin
  • mouth sores
  • hives
  • itching
  • hoarseness
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • chest pain
  • fast, pounding, or irregular heartbeat
  • frenzied, abnormally excited mood
  • hallucinating (seeing things or hearing voices that do not exist)
  • anxiety
  • depression
  • thinking about killing or harming yourself

How should I use Provigil to help with being tired from narcolepsy?

Provigil comes as a tablet to take by mouth. It is usually taken once a day with or without food. If you are taking Provigil to treat narcolepsy or OSAHS, you will probably take it in the morning. If you are taking Provigil to treat shift work sleep disorder, you will probably take it 1 hour before the beginning of your work shift. Take Provigil at the same time every day. Do not change the time of day that you take Provigil without talking to your doctor. Talk to your doctor if your work shift does not begin at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Provigil exactly as directed.

Provigil may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Provigil may decrease your sleepiness, but it will not cure your sleep disorder. Continue to take Provigil even if you feel well-rested. Do not stop taking Provigil without talking to your doctor.

Provigil should not be used in place of getting enough sleep. Follow your doctor's advice about good sleep habits. Continue to use any breathing devices or other treatments that your doctor has prescribed to treat your condition, especially if you have OSAHS.

Are there other uses for Provigil aside from sleep disorder treatment?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow when I take Provigil?

Before taking Provigil,
  • tell your doctor and pharmacist if you are allergic to Provigil, arProvigil (Nuvigil), or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); cyclosporine (Neoral, Sandimmune); diazepam (Valium); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); propranolol (Inderal); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); rifampin (Rifadin, Rimactane); and triazolam (Halcion). Many other medications may also interact with Provigil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications, especially stimulants. Also tell your doctor if you have ever had chest pain, an irregular heartbeat, or other heart problems after taking a stimulant, and if you have or have ever had high blood pressure; a heart attack; chest pain; a mental illness such as depression, mania (frenzied, abnormally excited mood), or psychosis (difficulty thinking clearly, communicating, understanding reality, and behaving appropriately); or heart, liver, or kidney disease.
  • you should know that Provigil may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while taking Provigil and for 1 month after you stop taking it. Talk to your doctor about types of birth control that will work for you during and after your treatment with Provigil.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Provigil, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Provigil.
  • you should know that Provigil may affect your judgment or thinking and may not completely relieve the sleepiness caused by your disorder. Do not drive a car or operate machinery until you know how this medication affects you. If you avoided driving and other dangerous activities because of your sleep disorder, do not start performing these activities again without talking to your doctor even if you feel more alert.
  • be aware that you should avoid drinking alcohol while taking Provigil.

Do I need to follow a special diet when on Provigil?

Talk to your doctor about eating grapefruit or drinking grapefruit juice while you are taking this medication.

What should I do if I forget a dose of Provigil?

You should skip the missed dose. Wait until the next time you are supposed to take Provigil, and then take your normal dose. If you take Provigil too late in your waking day, you may find it harder to go to sleep. Do not take a double dose to make up for a missed one.

What storage conditions are needed for Provigil?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Store Provigil in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

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